Protandim can improve mitochondrial function. It can help boost the availability of necessary proteins for ATP production. They also serve as antioxidants that assist the mitochondria in reducing oxidative stress. Lifestyle changes can be effective. Intermittent fasting, exercise, cold, ketogenic diet, oxaloacetate, malic acid, resveratrol, apigenin, leucine, and niacinamide can make a big difference.